Summary
The goal of this Notice of Funding Opportunity (NOFO) is to provide funding support for the pre-clinical and early stage clinical (Phase I) development of novel small-molecule and biologic drug candidates that prevent Alzheimer's disease (AD), slow its progression, or treat its cognitive and behavioral symptoms. Participants in this program will receive funding for therapy development activities such as medicinal chemistry; pharmacokinetics (PK); Absorption, Distribution, Metabolism, Excretion, Toxicology (ADMET); efficacy in animal models; development of biomarkers for target engagement; formulation development; chemical synthesis under Good Manufacturing Practices (GMP); Investigational New Drug (IND) enabling studies; and initial Phase I clinical testing. Applications not responsive to this NOFO include research on basic mechanisms of disease or mechanisms of drug action; development ofrisk, diagnostic, prognostic, predictive, and preventionbiomarkers, devices, non-pharmacological interventions (e.g., exercise, diet, cognitive training), repurposed drugs and combination therapies; discovery activities such as high-throughput screening and hit optimization; and stand-alone clinical trials.
Eligibility
- Public and State Institutions of Higher Education
- Public and Indian Housing Authorities
- Other
- Nonprofits Having A 501(c)(3) Status With the Irs Other Than Institutions of Higher Education
- Small Businesses
- Native American Tribal Organizations Other Than Federally Recognized Tribal Governments
- Private Institutions of Higher Education
- County Governments
- Native American Tribal Governments Federally Recognized
- Nonprofits Non Higher Education Without 501c3
- For Profit Organizations Other Than Small Businesses
- Special District Governments
- Independent School Districts
- State Governments
- City Or Township Governments
Funding categories
- Health
Official source and attribution
This directory republishes federal opportunity information sourced from Simpler.Grants.gov and Grants.gov. Local Business Ranks is not affiliated with or endorsed by the federal government. Always rely on the official opportunity record for application requirements and changes.
Open the official federal record