Summary
The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as demonstrated with supportive preliminary data, but require further mechanistic studies to test for their causality or predictability. Applicants pursuing early-stage research to identify host biological patterns that may affect probiotic health outcomes should consider the companion (R61/R33) NOFO PAR-AT-24-XXX (TEMP-25412).
Eligibility
- Private Institutions of Higher Education
- Native American Tribal Governments Federally Recognized
- Nonprofits Non Higher Education Without 501c3
- For Profit Organizations Other Than Small Businesses
- Small Businesses
- Other
- Public and State Institutions of Higher Education
- State Governments
- Independent School Districts
- Public and Indian Housing Authorities
- Nonprofits Having A 501(c)(3) Status With the Irs Other Than Institutions of Higher Education
- Special District Governments
- County Governments
- Native American Tribal Organizations Other Than Federally Recognized Tribal Governments
- City Or Township Governments
Funding categories
- Education
- Health
Official source and attribution
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