Summary
The National Institutes of Neurological Disorders and Stroke (NINDS) is interested in supporting research projects proposing the optimization and translational development of genomic and biologic therapeutic candidates for Alzheimer’s Disease-Related Dementias (ADRD). Breakthroughs in genomic and biologic therapies are creating new opportunities to treat, prevent, and potentially modify the course of dementias; however, progress is limited by challenges in delivery, safety, manufacturability, and readiness for clinical testing. This program is intended to support projects across the translational pipeline, from optimization through IND development and early clinical evaluation, for genomic and biologic therapeutic candidates with compelling preclinical evidence. Eligible projects may include activities to refine therapeutic design and manufacturability; establish pharmacology, toxicology, biodistribution, and in vivo efficacy; to generate the full body of data required to support regulatory interactions and IND submissions, and, when appropriate, first-in-human (FIH) clinical studies. The program is aligned with priorities from the ADRD Summits, including acceleration of disease-modifying therapeutic development in frontotemporal degeneration (FTD), Lewy body dementia (LBD), and vascular contributions to cognitive impairment and dementia (VCID). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
Eligibility
- Nonprofits Having A 501(c)(3) Status With the Irs Other Than Institutions of Higher Education
- Special District Governments
- County Governments
- Other
- Independent School Districts
- State Governments
- For Profit Organizations Other Than Small Businesses
- Nonprofits Non Higher Education Without 501c3
- Public and Indian Housing Authorities
- City Or Township Governments
- Private Institutions of Higher Education
- Small Businesses
- Native American Tribal Organizations Other Than Federally Recognized Tribal Governments
- Public and State Institutions of Higher Education
- Native American Tribal Governments Federally Recognized
Funding categories
- Health
Official source and attribution
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