Summary
PURPOSE NIOSH intends to support the Centers of Excellence in Total Worker Health® (TWH). These Centers will conduct rigorous research and translation activities to prevent harmful exposures, improve working conditions, and advance worker well-being. The Centers will develop practical, scalable solutions for employers and workers. All projects must use the NIOSH Worker Well-Being Questionnaire (WellBQ) and share data with the HERO Worker Well-Being Clearinghouse. Large Research Projects require economic evaluation. PRIORITY AREAS • High-risk occupations: First responders, vehicle mechanics, and technicians, with emphasis on occupational exposures, related health risks, and prevention strategies • Young workers, SMEs • Chronic disease • Mental health, stress • Substance use disorder • Artificial intelligence (AI), digital technologies This is a multi-component NOFO. COMPONENT STRUCTURE Percentages indicate maximum share of total budget. Overall Component (Required) Provides Center leadership and integration. Applicants should show strong coordination, scientific direction, and alignment across projects. Administration, Evaluation, and Emerging Issues Core (Required; up to 15%) Supports management and Center-wide evaluation. Applicants should describe oversight, data governance, and quality assurance.Optional activities include emerging issues and shared research resources. Outreach, Dissemination, and Impact Core (Required; up to 15%) Supports communication, worker/employer engagement, training, translation, implementation, and dissemination strategies. Research Projects (Required; about 60 to 70%) Includes all research activities. Applicants may propose a mix of projects. Research project distinctions are based on scope and complexity rather than cost. Projects should demonstrate scientific rigor and potential for sustained impact. • Small Research Projects (Required; at least one project; up to 3 years) Exploratory, feasibility, early-stage intervention, surveillance, or measurement studies. Priority areas: high-risk occupations, young workers, SMEs. Should show innovation and potential to expand. • Large Research Projects (Required; at least one project; up to 5 years) Multiyear etiologic, mechanistic, intervention, or translational studies. Priority areas: chronic disease, mental health, substance use disorder. Economic evaluation is required. Projects should include strong design and analytic plans. • Pilot/Feasibility Program (Optional; 12–18 months) Short-term studies generating preliminary data or testing AI/digital technology approaches.
Eligibility
- Unrestricted
- Nonprofits Having A 501(c)(3) Status With the Irs Other Than Institutions of Higher Education
- Independent School Districts
- Small Businesses
- State Governments
- Special District Governments
- Public and Indian Housing Authorities
- County Governments
- Native American Tribal Governments Federally Recognized
- For Profit Organizations Other Than Small Businesses
- Nonprofits Non Higher Education Without 501c3
- Native American Tribal Organizations Other Than Federally Recognized Tribal Governments
- City Or Township Governments
- Public and State Institutions of Higher Education
- Private Institutions of Higher Education
Funding categories
- Health
Official source and attribution
This directory republishes federal opportunity information sourced from Simpler.Grants.gov and Grants.gov. Local Business Ranks is not affiliated with or endorsed by the federal government. Always rely on the official opportunity record for application requirements and changes.
Open the official federal record