Summary
The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 of the SMaHT Genome Characterization Centers (GCCs) initiative. The SMaHT Stage 2 GCCs will determine the functional consequences of somatic mutations in healthy and clinically relevant tissue samples, the latter comprising patients whose phenotype is suspected to be driven by somatic mutations. This work will support the SMaHT Network's efforts to characterize somatic mosaicism and its role in human biology and disease.
Eligibility
- Nonprofits Having A 501(c)(3) Status With the Irs Other Than Institutions of Higher Education
- City Or Township Governments
- Private Institutions of Higher Education
- Independent School Districts
- For Profit Organizations Other Than Small Businesses
- State Governments
- County Governments
- Other
- Small Businesses
- Native American Tribal Organizations Other Than Federally Recognized Tribal Governments
- Nonprofits Non Higher Education Without 501c3
- Public and State Institutions of Higher Education
- Special District Governments
- Public and Indian Housing Authorities
- Native American Tribal Governments Federally Recognized
Funding categories
- Health
Official source and attribution
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