Summary
The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 through the National Somatic Mosaicism Commons Data Analysis & Organizational Center. The National Somatic Mosaicism Commons Data Analysis & Organizational Center combines data management and analysis with network governance, coordination, outreach, and training. The Center will develop tools and platforms that allow SMaHT Network members and the wider clinical and research communities to investigate and use these complex datasets. The center will be responsible for managing network data and providing access to data analysis tools developed in the program. This will include building the SMaHT data portal, Variant Catalog, variant browser, visualization tools, and analysis-ready releases. The center will also conduct outreach to clinical and research communities and provide training in SMaHT resources.
Eligibility
- Public and State Institutions of Higher Education
- Special District Governments
- For Profit Organizations Other Than Small Businesses
- County Governments
- Other
- Public and Indian Housing Authorities
- City Or Township Governments
- Private Institutions of Higher Education
- Nonprofits Non Higher Education Without 501c3
- Small Businesses
- Native American Tribal Organizations Other Than Federally Recognized Tribal Governments
- Nonprofits Having A 501(c)(3) Status With the Irs Other Than Institutions of Higher Education
- Native American Tribal Governments Federally Recognized
- Independent School Districts
- State Governments
Funding categories
- Health
Official source and attribution
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